I've finally admitted defeat every time I scan it and it is clean go to IE and off we go again scan and it found at least 5/6 instances of adware, then something it stopping the windows update service, everytime I start it it stops itself again for no rhyme or reason, then IE is so fuckin slow as well.
Just going to be a damn site easier I reckon to re-build, the only annoying thing is I'll lose all my emails as I don't think there is any program that can backup your inbox (unless anyone knows of anything ?)
That's my weekend sorted...and the Mrs moaning I spend more time on the computer than with her

Two points (that have already been made):
Why are you persisting in using IE then complaining about pop-ups, security holes etc?
Why aren't you using Spybot S&D or Hitman as others have advised? Adaware doesn't catch a fraction of what they do
And apologies if you've already answered those in the rest of this thread. Life's too short and all